Monitor lizards differ greatly from other lizards in several ways, possessing a relatively high metabolic rate for reptiles, and several sensory adaptations that benefit the hunting of live prey. Recent research indicates the varanid lizards may have some venom. This discovery of venom in monitor lizards, as well as in agamid lizards, led to the Toxicofera hypothesis: that all venomous lizards and snakes share a common venomous ancestor.
During the late Cretaceous era, monitor lizards or their close relatives are believed to have evolved into amphibious and then fully marine forms, the mosasaurs, which reached lengths of up to 17 m.

Monitor lizards differ greatly from other lizards in several ways, possessing a relatively high metabolic rate for reptiles, and several sensory adaptations that benefit the hunting of live prey. Recent research indicates the varanid lizards may have some venom. This discovery of venom in monitor lizards, as well as in agamid lizards, led to the Toxicofera hypothesis: that all venomous lizards and snakes share a common venomous ancestor.
During the late Cretaceous era, monitor lizards or their close relatives are believed to have evolved into amphibious and then fully marine forms, the mosasaurs, which reached lengths of up to 17 m.